Article Sidebar

Download
View Article
Statistic
Read Counter : 12 Download : 6

Main Article Content

Abstract

General Background: Chronic viral hepatitis (CH) poses a significant challenge in contemporary healthcare, leading to severe liver diseases such as cirrhosis and hepatocellular carcinoma. Specific Background: Among the known hepatotropic viruses, hepatitis B, C, D, and G are implicated in chronic liver conditions, with hepatitis C virus (HCV) being particularly concerning in co-infected populations, such as children with HIV. Knowledge Gap: While the progression of liver fibrosis in CH is well-documented, the interplay of risk factors affecting fibrosis progression in HIV-infected children remains underexplored. Aims: This study aims to assess the risk factors influencing liver fibrosis in children diagnosed with chronic hepatitis C and co-infected with HIV, emphasizing the need for timely diagnosis and management. Results: Preliminary findings indicate that HIV co-infection significantly exacerbates the progression of liver fibrosis in children with chronic hepatitis C, highlighting age, immune status, and viral load as critical factors. Novelty: This research provides novel insights into the unique clinical presentation of liver disease in pediatric HIV-positive populations, which is often overlooked in current literature. Implications: The implications of this study are profound, suggesting that healthcare providers must prioritize regular screening for liver fibrosis in this vulnerable demographic to improve clinical outcomes and inform therapeutic strategies. Addressing this issue could lead to enhanced management protocols for co-infected children, ultimately reducing morbidity associated with chronic liver disease.

Keywords

Chronic Viral ¬Hepatitis Fibrosis Liver Cirrhosis

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite
Isakovna, K. D. (2024). DIAGNOSIS OF LIVER FIBROSIS IN CHRONIC VIRAL HEPATITIS C IN HIV-INFECTED CHILDREN. Journal of Medical Genetics and Clinical Biology, 1(9), 84–88. https://doi.org/10.61796/jmgcb.v1i9.962
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Y. J. Choi et al., "Prevalence of Renal Dysfunction in Patients with Cirrhosis According to ADQI-IAC Working Party Proposal," Clinical and Molecular Hepatology, vol. 20, pp. 185–191, 2014. doi: 10.3350/cmh.2014.20.2.185.
  2. A. R. Oblokulov, M. I. Mukhammadieva, S. A. Sanokulova, D. I. Khadieva, "Clinical and Laboratory Features of Spontaneous Bacterial Peritonitis in Patients with Viral Liver Cirrhosis," Journal of Advanced Zoology, vol. 44, no. S-2, pp. 3744–3750, 2023. Available: http://jazindia.com/index.php/jaz/article/view/1716.
  3. K. B. Russ, T. M. Stevens, and A. K. Singal, "Acute Kidney Injury in Patients with Cirrhosis," Journal of Clinical and Translational Hepatology, vol. 3, pp. 195–204, 2015.
  4. A. S. Allegretti et al., "Prognosis of Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis: A Prospective Cohort Study," International Journal of Nephrology, vol. 2015, Article ID 108139, 2015. doi: 10.1155/2015/108139.
  5. E. Cholongitas et al., "Cirrhotics Admitted to Intensive Care Unit: The Impact of Acute Renal Failure on Mortality," European Journal of Gastroenterology and Hepatology, vol. 21, pp. 744–750, 2009. doi: 10.1097/MEG.0b013e328308bb9c.
  6. A. Barbaud et al., "Comparison of Cytokine Gene Polymorphism in Drug-Induced Maculopapular Eruption, Urticaria and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)," Journal of the European Academy of Dermatology and Venereology, vol. 28, no. 4, pp. 491–499, 2014. doi: 10.1111/jdv.12130.
  7. K. D. Isakovna, "Diagnosis and Prognosis of Liver Fibrosis in Chronic Viral Hepatitis C in HIV-Infected Children," Journal of Healthcare and Life-Science Research, vol. 3, no. 5, pp. 127-133, 2024.
  8. M. I. Mukhammadieva, "Improvement of Primary Prophylaxis and Treatment of Spontaneous Bacterial Peritonitis Complicated in Virus Etiology Liver Cirrhosis," Journal of Intellectual Property and Human Rights, vol. 3, no. 4, pp. 19–25, 2024. Available: http://journals.academiczone.net/index.php/jiphr/article/view/2506.
  9. A. A. Elmurodova, "Viral Hepatitis Delta: An Underestimated Threat," Texas Journal of Medical Science, vol. 26, pp. 1–3, 2023. Available: https://zienjournals.com/index.php/tjms/article/view/4610.
  10. M. I. Mukhammadieva et al., "Modern Clinical and Biochemical Characteristics of Liver Cirrhosis Patients of Viral Etiology with Spontaneous Bacterial Peritonitis," Texas Journal of Medical Science, vol. 26, pp. 86-90, 2022.
  11. M. Z. Abdulloev, "Modern Therapy of Viral Hepatitis," Texas Journal of Medical Science, vol. 26, pp. 66–69, 2023. Available: https://www.zienjournals.com/index.php/tjms/article/view/4636.
  12. A. R. Oblokulov and M. I. Mukhammadieva, "Clinical and Biochemical Characteristics of Liver Cirrhosis Patients of Viral Etiology with Spontaneous Bacterial Peritonitis," Academicia Globe: Inderscience Research, vol. 2022, pp. 210–216, 2022.
  13. S. A. Khadieva, "Factors of Development of Hepatorenal Syndrome in Patients with Liver Cirrhosis of Viral Etiology," Texas Journal of Medical Science, vol. 26, pp. 4–9, 2023. Available: https://www.zienjournals.com/index.php/tjms/article/view/4611.
  14. S. A. Sanokulova, "Factors of Development of Hepatorenal Syndrome in Patients with Liver Cirrhosis of Viral Etiology," Amaliy Va Tibbiyot Fanlari Ilmiy Jurnali, vol. 2, no. 12, pp. 1–8, 2023. Available: https://www.sciencebox.uz/index.php/amaltibbiyot/article/view/8673.
  15. A. S. Jalilova, "The Spread of Cirrhosis of the Liver by Etiological Factors," Oriental Renaissance: Innovative, Educational, Natural and Social Sciences, vol. 2, no. 6, pp. 253–257, 2022.
  16. M. R. Aslonova, "Modern Approaches to Treatment of Chronic Giardiasis," Central Asian Journal of Medical and Natural Science, vol. 3, no. 2, pp. 102-105, 2022. Available: https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/631.
  17. A. S. Jalilova, "Approaches to Etiotropic Therapy of COVID-19 in Outpatient Patients," International Journal of Health Systems and Medical Sciences, vol. 1, no. 1, pp. 41–44, 2022.
  18. S. A. Mukhtarova, "Age-Related Features of Clinical Manifestations of Giardiasis," International Journal of Medical Sciences and Clinical Research, vol. 2022, pp. 17–21, 2022.
  19. A. S. Jalilova, "Features of Clinical Manifestations of Cytomegalovirus Infection in Children," International Journal of Medical Sciences and Clinical Research, vol. 2, no. 9, pp. 12–16, 2022. doi: 10.37547/ijmscr/Volume02Issue09-04.
  20. O. A. Raximovich et al., "Microbiological Indicators of Patients with Confirmed SARS-CoV-2 Infection," Central Asian Journal of Medical and Natural Science, vol. 3, no. 2, pp. 289-294, 2022. doi: 10.17605/OSF.IO/9CFP6.
  21. M. Sh. Abdulloevna, "Prevention of Seasonal Spread of ARVI Among Young Children," Amaliy Va Tibbiyot Fanlari Ilmiy Jurnali, vol. 2, no. 12, pp. 22–28, 2023. Available: https://www.sciencebox.uz/index.php/amaltibbiyot/article/view/8678.