Main Article Content
Abstract
General Background: Mycotoxins, toxic substances produced by certain fungi and bacteria, pose significant health risks to humans and animals, necessitating effective remediation strategies. Specific Background: The use of environmentally friendly approaches to mitigate the impact of these toxins is crucial. Nanotechnology, particularly in conjunction with plant extracts, has emerged as a promising method for toxin remediation due to its cost-effectiveness and efficiency. Knowledge Gap: Despite the potential of nanomaterials in mycotoxin management, there is limited research exploring the interaction between plant extracts and nanotechnology in inhibiting toxin-producing fungi. Aims: This study aims to investigate the efficacy of zinc oxide nanomaterials synthesized from mint plant extracts in mitigating the effects of mycotoxins and inhibiting the growth of mycotoxin-producing fungi. Results: Mint leaves were collected from various locations in Al-Qadisiyah Governorate over an eight-week period. The extracted plant materials were used to synthesize zinc oxide nanoparticles, which demonstrated significant inhibitory effects on the growth of specific fungi responsible for mycotoxin production, thereby reducing mycotoxin formation. Novelty: This research highlights the innovative application of mint-derived zinc oxide nanoparticles as a dual-action agent—suppressing fungal growth while simultaneously preventing mycotoxin synthesis. Implications: The findings provide valuable insights into sustainable agricultural practices and mycotoxin management, paving the way for the development of natural, eco-friendly solutions to enhance food safety and protect public health.
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References
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References
Aiad, I., El-Sukkary, M. M., Soliman, E. A., El-Awady, M. Y., and Shaban, S. M., "In Situ and Green Synthesis of Silver Nanoparticles and Their Biological Activity," Journal of Industrial and Engineering Chemistry, vol. 20, no. 5, pp. 3430-3439, 2014.
Ashour, E. A., El-Hack, M. E. A., Shafi, M. E., Alghamdi, W. Y., Taha, A. E., Swelum, A. A., and El-Saadony, M. T., "Impacts of Green Coffee Powder Supplementation on Growth Performance, Carcass Characteristics, Blood Indices, Meat Quality and Gut Microbial Load in Broilers," Agriculture, vol. 10, no. 10, p. 457, 2020.
Aslam, N., Rodrigues, I., McGill, D. M., Warriach, H. M., Cowling, A., Haque, A., and Wynn, P. C., "Transfer of Aflatoxins from Naturally Contaminated Feed to Milk of Nili-Ravi Buffaloes Fed a Mycotoxin Binder," Animal Production Science, vol. 56, no. 10, pp. 1637-1642, 2015.
Atef, A. H., Noha, H. O., and Manal, M., "Detection of Mycotoxigenic Fusarium Species in Poultry Rations and Their Growth Control by Zinc Nanoparticles," Journal of Environmental Science and Technology, vol. 15, no. 4, pp. 327-338, 2021.
Cheat, S., Oswald, I. P., and Kolf-Clauw, M., "Mycotoxin Outbreak in Animal Feed," in Foodborne Diseases Case Studies of Outbreaks in the Agri-Food Industries, pp. 411, 2016.
Cunha, S. C., Sa, S. V., and Fernandes, J. O., "Multiple Mycotoxin Analysis in Nut Products: Occurrence and Risk Characterization," Food and Chemical Toxicology, vol. 114, pp. 260-269, 2018.
Dellafiora, L., Dall'Asta, C., and Galaverna, G., "Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment—An In Silico Perspective," Toxins, vol. 10, no. 2, p. 52, 2018.
El-Hamaky, A. M., Hassan, A. A., El Yazeed, H. A., and Refai, M. K., "Prevalence and Detection of Toxigenic A. flavus, A. niger, and A. ochraceus by Traditional and Molecular Biology Methods in Feeds," International Journal of Current Research, vol. 8, no. 1, pp. 25621-25633, 2016.
El-Hamaky, A. M., Hassan, A. A., Wahba, A. K., and El-Mosalamy, M. M., "Influence of Copper and Zinc Nanoparticles on Genotyping Characterizations of Multi-Drug Resistance Genes for Some Calf Pathogens," International Journal of Veterinary Science and Research, vol. 9, no. 2, pp. 90-99, 2023.
Elkenany, R., and Awad, A., "Types of Mycotoxins and Different Approaches Used for Their Detection in Foodstuffs," Mansoura Veterinary Medical Journal, vol. 22, no. 1, pp. 25-32, 2021.
El-Sayed, R. A., Jebur, A. B., Kang, W., and El-Demerdash, F. M., "An Overview on the Major Mycotoxins in Food Products: Characteristics, Toxicity, and Analysis," Journal of Future Foods, vol. 2, no. 2, pp. 91-102, 2022.
El-Tarabily, K. A., El-Saadony, M. T., Alagawany, M., Arif, M., Batiha, G. E., Khafaga, A. F., and Abd El-Hack, M. E., "Using Essential Oils to Overcome Bacterial Biofilm Formation and Their Antimicrobial Resistance," Saudi Journal of Biological Sciences, vol. 28, no. 9, pp. 5145-5156, 2021.
Freire, L., and Sant'Ana, A. S., "Modified Mycotoxins: An Updated Review on Their Formation, Detection, Occurrence, and Toxic Effects," Food and Chemical Toxicology, vol. 111, pp. 189-205, 2018.
Gacem, M. A., Gacem, H., Telli, A., and Khelil, A. O. E. H., "Mycotoxins: Decontamination and Nanocontrol Methods," in Nanomycotoxicology, Academic Press, pp. 189-216, 2020.
Geethalakshmi, R., and Sarada, D. V. L., "Characterization and Antimicrobial Activity of Gold and Silver Nanoparticles Synthesized Using Saponin Isolated from Trianthema Decandra L.," Industrial Crops and Products, vol. 51, pp. 107-115, 2013.
Horky, P., Skalickova, S., Baholet, D., and Skladanka, J., "Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins," Nanomaterials, vol. 8, no. 9, p. 727, 2018.
Jayachandran, A., Aswathy, T. R., and Nair, A. S., "Green Synthesis and Characterization of Zinc Oxide Nanoparticles Using Cayratia Pedata Leaf Extract," Biochemistry and Biophysics Reports, vol. 26, p. 100995, 2021.
Jiang, K., Huang, Q., Fan, K., Wu, L., Nie, D., Guo, W., and Han, Z., "Reduced Graphene Oxide and Gold Nanoparticle Composite-Based Solid-Phase Extraction Coupled with Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry for the Determination of 9 Mycotoxins in Milk," Food Chemistry, vol. 264, pp. 218-225, 2018.
Jogee, P., and Rai, M., "Application of Nanoparticles in Inhibition of Mycotoxin-Producing Fungi," in Nanomycotoxicology, Academic Press, pp. 239-250, 2020.
Kołodziejczak-Radzimska, A., and Jesionowski, T., "Zinc Oxide—from Synthesis to Application: A Review," Materials, vol. 7, no. 4, pp. 2833-2881, 2014.
Krstanovic, V., Šarkanj, B., Velic, N., Mastanjevic, K., Šantek, B., and Mastanjevic, K., "Mycotoxins in Malting and Brewing By-Products Used for Animal Feed," in European Biotechnology Congress 2017, pp. S68-S69, 2017.
Moodley, J. S., Krishna, S. B. N., Pillay, K., Sershen, F., and Govender, P., "Green Synthesis of Silver Nanoparticles from Moringa Oleifera Leaf Extracts and Its Antimicrobial Potential," Advances in Natural Sciences: Nanoscience and Nanotechnology, vol. 9, no. 1, p. 015011, 2018.
Mukunthan, K. S., and Balaji, S., "Cashew Apple Juice (Anacardium Occidentale L.) Speeds Up the Synthesis of Silver Nanoparticles," International Journal of Green Nanotechnology, vol. 4, no. 2, pp. 71-79, 2012.
Nayak, R., Ali, F. A., Mishra, D. K., Ray, D., Aswal, V. K., Sahoo, S. K., and Nanda, B., "Fabrication of CuO Nanoparticle: An Efficient Catalyst Utilized for Sensing and Degradation of Phenol," Journal of Materials Research and Technology, vol. 9, no. 5, pp. 11045-11059, 2020.
Ouda, S. M., "Antifungal Activity of Silver and Copper Nanoparticles on Two Plant Pathogens, Alternaria Alternata and Botrytis Cinerea," Research Journal of Microbiology, vol. 9, no. 1, pp. 34-40, 2014.
Pelaz, B., Jaber, S., De Aberasturi, D. J., Wulf, V., Aida, T., de la Fuente, J. M., and Parak, W. J., "The State of Nanop